Andy (Charlize Theron) and her team continue their mission to protect humanity, but find themselves targeted by Discord (Uma Thurman), a mysterious figure claiming to be the first and oldest immortal. Simultaneously, the long-lost immortal Quynh (Veronica Ngô) resurfaces after 500 years of drowning, fueled by vengeance and a dark philosophy that immortality is a curse meant to bring suffering. As Andy grapples with her newfound mortality, the team must navigate betrayals and uncover secrets of their existence with the help of a new ally, Tuah (Henry Golding).